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Bicalutamide didn't have AR agonist activity in these cells but it was unable to inhibit basal AF-2-unbiased AR transcriptional activity, suggesting that uncoupling of the NH2-terminal AF-1 transactivation function from AF-2 (by unclear mechanisms) could contribute to bicalutamide resistance in androgen-unbiased prostate cancer ( forty seven ).
United kingdom - The Committee on Security of medicines has suggested that for patients with localized prostate cancer, the balanced threat good thing about biculatimide is unfavourable and the product is no longer licensed for the therapy of this situation. getting off bicalutamide are almost always reversible and can go away after treatment is full.
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